Dunnwald L K, Mankoff D A, Byrd D R, Anderson B O, Moe R E, Yeung R S, Eary J F
Division of Nuclear Medicine, University of Washington, Seattle 98195, USA.
J Nucl Med Technol. 1999 Jun;27(2):106-11.
A significant morbidity risk is associated with axillary nodal dissections for breast cancer. Many treatment decisions are based on axillary nodal status. Lymphatic mapping and sentinel node biopsy have been investigated to determine if the histology of the sentinel node reflects the remaining lymph node basin. We describe the technical aspects of sentinel node lymphoscintigraphy for breast cancer.
Ninety-three patients had lymphoscintigraphy for breast cancer. Patients with palpable lesions had 4 concentric injections around the site and lesions requiring localization had injections made through tubing connected to the localizing wire introducer needle. Immediate static images were acquired and the sentinel node was marked for surgery. Marks were reverified using a handheld gamma probe.
Lymph nodes were visualized by lymphoscintigraphy in 87% of cases. Time to visualization of lymph nodes ranged from 1-120 min with a mean of 28 min. An average of 1.5 nodes were visualized. The overall success rate for identifying the sentinel node at time of surgery was 85%.
We conclude that lymphoscintigraphy for breast cancer is a detailed procedure that requires coordination with radiology and surgery teams to ensure proper identification of sentinel lymph nodes.
乳腺癌腋窝淋巴结清扫术存在显著的发病风险。许多治疗决策基于腋窝淋巴结状态。已对淋巴绘图和前哨淋巴结活检进行研究,以确定前哨淋巴结的组织学是否反映其余淋巴结区域的情况。我们描述了乳腺癌前哨淋巴结淋巴闪烁显像的技术要点。
93例患者接受了乳腺癌淋巴闪烁显像。有可触及病变的患者在病变部位周围进行4次同心注射,需要定位的病变通过连接到定位导丝引入针的导管进行注射。采集即时静态图像,并标记前哨淋巴结以便手术。使用手持式γ探测器再次确认标记。
87%的病例通过淋巴闪烁显像可看到淋巴结。淋巴结显影时间为1至120分钟,平均28分钟。平均可见1.5个淋巴结。手术时识别前哨淋巴结的总体成功率为85%。
我们得出结论,乳腺癌淋巴闪烁显像术是一个需要与放射科和手术团队协调的详细程序,以确保正确识别前哨淋巴结。