鲍温病显示与细胞凋亡相关的自发完全消退。

Bowen's disease showing spontaneous complete regression associated with apoptosis.

作者信息

Chisiki M, Kawada A, Akiyama M, Itoh Y, Tajima S, Ishibashi A, Yudate F

机构信息

Department of Dermatology, National Defense Medical College, Namiki 3-2, Tokorozawa, Saitama 359-0042, Japan.

出版信息

Br J Dermatol. 1999 May;140(5):939-44. doi: 10.1046/j.1365-2133.1999.02831.x.

DOI:10.1046/j.1365-2133.1999.02831.x

PMID:10354038

Abstract

Spontaneous regression is sometimes seen in malignant skin tumours. We report a 68-year-old woman whose Bowen's disease showed spontaneous complete regression. Prominent infiltration of T cells and increased vascularity were found in the upper dermis of the regressed lesion. Strong expression of Fas (APO-1/CD95) antigen, an apoptosis-related tumour necrosis factor receptor family protein, in the primary lesion and faint expression following regression suggest the involvement of Fas-mediated apoptosis in the spontaneous complete regression of our patient's Bowen's disease.

摘要

恶性皮肤肿瘤有时会出现自发消退的情况。我们报告了一名68岁女性，其鲍温病出现了自发完全消退。在消退病变的真皮上层发现了T细胞的显著浸润和血管增多。Fas（APO-1/CD95）抗原是一种与凋亡相关的肿瘤坏死因子受体家族蛋白，在原发性病变中强表达，消退后表达减弱，这表明Fas介导的凋亡参与了我们这位患者鲍温病的自发完全消退过程。