[母体对父体的反应性——取决于病因]
[Maternal anti-paternal reactivity--depends on etiology].
作者信息
Schütt C
机构信息
Institut für Immunologie und Transfusionsmedizin, Ernst-Moritz-Arndt-Universität Greifswald.
出版信息
Zentralbl Gynakol. 1999;121(4):202-5.
PMID:10355099
Abstract
Since TH1-cytokines compromise pregnancy and TH2-cytokines are produced at the maternal-fetal interface one can hypothesize that TH2-cytokines improve fetal survival. Cytotoxic T- or NK-cells are unable to recognize MHCI/II-negative trophoblast or become inactivated by HLA-G expression, respectively. Normal delivery at term might be assisted by a rapid reversal of the TH2 cytokine bias. Thus, the maternal immune state is most beneficial to reproductive fitness.
摘要
由于TH1细胞因子会损害妊娠，而TH2细胞因子在母胎界面产生，因此可以推测TH2细胞因子能提高胎儿存活率。细胞毒性T细胞或NK细胞分别无法识别MHCI/II阴性的滋养层细胞，或因HLA-G表达而失活。足月顺产可能得益于TH2细胞因子偏向的快速逆转。因此，母体免疫状态对生殖健康最为有利。
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