成人浅表软组织肉瘤的预后因素：105例患者的系列分析
Prognostic factors in superficial adult soft tissue sarcomas: analysis of a series of 105 patients.
作者信息
Cany L, Stoeckle E, Coindre J M, Kantor G, Bonichon F, Bui B N
机构信息
Department of Medical Oncology, Institut Bergonié Regional Cancer Center, Bordeaux, France.
出版信息
J Surg Oncol. 1999 May;71(1):4-9. doi: 10.1002/(sici)1096-9098(199905)71:1<4::aid-jso2>3.0.co;2-w.
BACKGROUND AND OBJECTIVES
This study was undertaken to study the behavior of superficial soft tissue sarcomas (STS) and determine the factors related to prognosis.
METHODS
The clinical records of 105 adults (56 men, 49 women, mean age: 56.4 years) were retrospectively analyzed. Univariate analysis was performed on the entire group for overall survival (OS), and metastasis-free survival (MFS). Local recurrence-free survival (LRFS) was studied only on patients first treated in our institute.
RESULTS
With a median follow-up of 111.9 months, 66 (62.9%) patients were alive; 25 (23.8%) had died of their disease. For the entire series, 10-year OS and MFS were 62.5% and 71.9% respectively. For fifty-two patients treated for their sarcoma at the Institution since the first tumor occurrence event, 10-year LRFS was 80%. Tumor grade was the only factor correlated with OS and MFS, while tumor size was the main factor correlated with LRFS.
CONCLUSION
Tumor size affects local control in STS while tumor grade is correlated with OS and MFS.
背景与目的
本研究旨在探讨浅表软组织肉瘤（STS）的行为，并确定与预后相关的因素。
方法
回顾性分析105例成年人（56例男性，49例女性，平均年龄：56.4岁）的临床记录。对整个组进行总生存（OS）和无转移生存（MFS）的单因素分析。仅对在我院首次接受治疗的患者研究无局部复发生存（LRFS）。
结果
中位随访111.9个月，66例（62.9%）患者存活；25例（23.8%）死于疾病。对于整个系列，10年OS和MFS分别为62.5%和71.9%。自首次肿瘤发生事件以来在该机构接受肉瘤治疗的52例患者，10年LRFS为80%。肿瘤分级是与OS和MFS相关的唯一因素，而肿瘤大小是与LRFS相关的主要因素。
结论
肿瘤大小影响STS的局部控制，而肿瘤分级与OS和MFS相关。
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