西酞普兰治疗中断的药代动力学后果。

Pharmacokinetic consequences of a citalopram treatment discontinuation.

作者信息

Voirol P, Rubin C, Bryois C, Kosel M, Buclin T, Baumann P

机构信息

University Department of Adult Psychiatry, Prilly-Lausanne, Switzerland.

出版信息

Ther Drug Monit. 1999 Jun;21(3):263-6. doi: 10.1097/00007691-199906000-00001.

DOI:10.1097/00007691-199906000-00001

PMID:10365634

Abstract

In this pilot study, the pharmacokinetics of citalopram (CIT) were examined in five hospitalized depressed patients after an abrupt discontinuation of a treatment with 40 mg/d of this selective serotonin reuptake inhibitor (SSRI). During the 8-day study period, clinical ratings were regularly carried out. Between days 5 and 8, the patients were treated with clomipramine (75 mg/d). The enantiomers of CIT and its metabolites, demethyl-CIT (DCIT) and CIT-propionic acid derivative (CIT-PROP), were measured repeatedly from day 0 to day 8 by a stereoselective high-performance liquid chromatography (HPLC) procedure. The following drug plasma half-lives were measured (means +/- SD): R-CIT: 66+/-11 h; S-CIT: 42+/-13 h; R-DCIT: 228+/-148 h; S-DCIT: 93+/-35 h; R-CIT-PROP: 82+/-31 h; S-CIT-PROP: 186+/-93 h.

摘要

在这项初步研究中，对5名住院抑郁症患者在突然停用40毫克/天的这种选择性5-羟色胺再摄取抑制剂（SSRI）治疗后进行了西酞普兰（CIT）的药代动力学研究。在为期8天的研究期间，定期进行临床评分。在第5天至第8天，患者接受氯米帕明（75毫克/天）治疗。从第0天至第8天，通过立体选择性高效液相色谱（HPLC）程序反复测量CIT及其代谢产物去甲基西酞普兰（DCIT）和西酞普兰丙酸衍生物（CIT-PROP）的对映体。测量了以下药物血浆半衰期（平均值±标准差）：R-CIT：66±11小时；S-CIT：42±13小时；R-DCIT：228±148小时；S-DCIT：93±35小时；R-CIT-PROP：82±31小时；S-CIT-PROP：186±93小时。