Shingleton B J, Chaudhry I M, O'Donoghue M W, Baylus S L, King R J, Chaudhry M B
Ophthalmic Consultants of Boston, Center for Eye Research, Massachusetts 02114, USA.
Ophthalmology. 1999 Jun;106(6):1152-5. doi: 10.1016/S0161-6420(99)90252-X.
To compare the effectiveness of limbus-based and fornix-based conjunctival flaps in fellow eyes of the same patients undergoing combined trabeculectomy with phacoemulsification.
Prospective, nonrandomized comparative (fellow eye) study.
Forty-four patients and 88 fellow eyes.
Limbus-based conjunctival flap with phacotrabeculectomy was performed in one eye, and a fornix-based conjunctival flap with phacotrabeculectomy was performed in the fellow eyes of the same patients. The patients were followed up for a minimum of 1 year postoperatively for each eye.
Preoperative and postoperative visual acuity, intraocular pressure, number of antiglaucoma medications, interventions, and complications were studied.
At last follow-up visit, visual acuity improved to 20/40 or better in 88.6% of the limbus-based group and 79.6% of the fornix-based group. Preoperatively, the mean intraocular pressure in the limbus-based group was 21.4 +/- 4.8 mmHg on a mean of 2.4 +/- 1.2 glaucoma medications; in the fornix-based group, it was 21.4 +/- 4.3 mmHg on a mean of 2.3 +/- 1.1 medications. Mean intraocular pressure decreased to 15.3 +/- 3.3 mmHg (P < 0.01) on a mean of 0.2 +/- 0.5 glaucoma medications in the limbus-based group (P < 0.01). In the fornix-based group, mean intraocular pressure at last follow-up visit decreased to 15.3 +/- 4.7 mmHg (P < 0.01) on a mean of 0.2 +/- 0.5 medications (P < 0.01). Postoperative interventions and complications were not statistically different between the two groups.
With phacotrabeculectomy, limbus-based and fornix-based conjunctival flaps are equally effective in improving visual acuity and lowering intraocular pressure. This variation in conjunctival flap orientation was equally effective in fellow eyes of the same patients, with no difference in postoperative complications or outcomes.
比较在接受小梁切除术联合白内障超声乳化吸除术的同一患者的对侧眼中,以角膜缘为基底的结膜瓣和以穹窿为基底的结膜瓣的有效性。
前瞻性、非随机对照(对侧眼)研究。
44例患者及88只对侧眼。
一只眼行以角膜缘为基底的结膜瓣小梁切除术,同一患者的对侧眼行以穹窿为基底的结膜瓣小梁切除术。每只眼术后至少随访1年。
研究术前及术后视力、眼压、抗青光眼药物使用数量、干预措施及并发症。
在最后一次随访时,以角膜缘为基底的结膜瓣组88.6%的患者视力提高到20/40或更好,以穹窿为基底的结膜瓣组为79.6%。术前,以角膜缘为基底的结膜瓣组平均眼压为21.4±4.8 mmHg,平均使用2.4±1.2种抗青光眼药物;以穹窿为基底的结膜瓣组平均眼压为21.4±4.3 mmHg,平均使用2.3±1.1种药物。以角膜缘为基底的结膜瓣组平均眼压降至15.3±3.3 mmHg(P<0.01),平均使用0.2±0.5种抗青光眼药物(P<0.01)。在以穹窿为基底的结膜瓣组,最后一次随访时平均眼压降至15.3±4.7 mmHg(P<0.01),平均使用0.2±0.5种药物(P<0.01)。两组术后干预措施和并发症无统计学差异。
对于小梁切除术联合白内障超声乳化吸除术,以角膜缘为基底的结膜瓣和以穹窿为基底的结膜瓣在提高视力和降低眼压方面同样有效。这种结膜瓣方向的差异在同一患者的对侧眼中同样有效,术后并发症或结果无差异。