妄想性障碍躯体型与局部脑血流减少之间可能存在的关联。
Possible association between delusional disorder, somatic type and reduced regional cerebral blood flow.
作者信息
Wada T, Kawakatsu S, Komatani A, Okuyama N, Otani K
机构信息
Department of Neuropsychiatry, Yamagata University School of Medicine, Japan.
出版信息
Prog Neuropsychopharmacol Biol Psychiatry. 1999 Feb;23(2):353-7. doi: 10.1016/s0278-5846(98)00098-0.
Abstract
- A 78-year-old female with DDST and pain disorder was treated by clomipramine 20-100 mg/day. The hypochondriacal delusion was completely resolved, while the pains were partially resolved. 2. The SPECT using Xe-133 taken at the early stage of clomipramine treatment, when she still had hypochondriacal delusions, showed markedly reduced rCBF in the temporal and parietal lobes, with predominance on the left hemisphere. Meanwhile, the SPECT taken after resolution of the hypochondriacal delusions showed a marked improvement in the reduced rCBF. 3. This report suggests that DDST has some association with reduced rCBF in the temporal and parietal lobes.
摘要
- 一名患有妄想性抑郁症和疼痛障碍的78岁女性，接受了每日20 - 100毫克氯米帕明的治疗。疑病妄想完全消除，而疼痛部分缓解。2. 在氯米帕明治疗早期，当她仍有疑病妄想时进行的使用Xe - 133的单光子发射计算机断层扫描（SPECT）显示，颞叶和顶叶的局部脑血流（rCBF）明显降低，以左半球为主。同时，疑病妄想消除后进行的SPECT显示，降低的rCBF有显著改善。3. 本报告表明，妄想性抑郁症与颞叶和顶叶rCBF降低存在一定关联。
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