Effect of oral pretreatment with ethyl apovincaminate on the cardiac output and nutritive blood flow of various organs in rats.

Effect of ethyl apovincaminate (RGH-4405, Cavinton), administered repeatedly p.o. in doses of 0.5-1.5-4.5 mg/100 g body weight for 5 days, on cardiac output and organ fractions of cardiac output were studied in rats anaesthetized with sodium pentobarbital by Evans-blue dilution and isotope fractionation technique of Sapirstein. Cardiac output, cerebral, coronary, renal, intestinal and dermal blood flow was increased by 18-42% after 4.5 mg/100 g Cavinton, while blood pressure was unaltered. Total peripheral resistance, cerebral, coronary, dermal resistance and that of the carcass decreased significantly. Organ fractions of the cardiac output were not significantly altered after treatment.