Wang Z, Liang G, Yin Q
Institute of Orthopaedics, Xijing Hospital, Fourth Milcitary Medical University, Xi'an.
Zhonghua Wai Ke Za Zhi. 1997 Apr;35(4):200-3.
The advantages of segmental allografts over arthoplastics are, among others, secured biological healing, easy attachment of tendons and ligaments, and desirable long-tem results. Since 1983, the authors have performed 35 resections of malignant tumors in the extremities followed by reconstructions with implantation of segmental allografts. Five types of grafts were used for the reconstruction of the skeletal defects, intercalary hemicylinder, intercalary cylinder, partial osteoarticular, total osteoarticular, and allograft-prosthetic implant composite. All the patients underwent adjunctive chemotherapy that was considered necessary. The length of follow-up ranged from 6 months to 10 years during which time 6 patients died, 25 were disease-free, and 4 survived as tumors-carriers. Complications in 28.6% of the patients included infection, graft resorption, recurrence and nonunion. Patients undergoing intercalary grafts oblained better functional results than those having osteoarticular grafts. 4 patients had biopsies and bone scans of the grafts 2-4 years postoperation with creeping substituion being observed. Segmental allograft remains a viable approach with predictable results for reconstruction of skeletal defects after resection of malignant bone tumors.
节段性同种异体移植相对于关节成形术的优点包括生物愈合可靠、肌腱和韧带附着容易以及长期效果理想等。自1983年以来,作者共进行了35例肢体恶性肿瘤切除手术,随后植入节段性同种异体移植物进行重建。使用了五种类型的移植物来重建骨骼缺损,即节段间半圆柱体、节段间圆柱体、部分骨关节、全骨关节以及同种异体移植物-假体植入复合物。所有患者均接受了认为必要的辅助化疗。随访时间为6个月至10年,在此期间,6例患者死亡,25例无病生存,4例带瘤生存。28.6%的患者出现了并发症,包括感染、移植物吸收、复发和骨不连。接受节段间移植物的患者比接受骨关节移植物的患者功能恢复更好。4例患者在术后2至4年对移植物进行了活检和骨扫描,观察到有骨爬行替代现象。节段性同种异体移植仍然是一种可行的方法,对于恶性骨肿瘤切除术后骨骼缺损的重建具有可预测的效果。