dl-3-正丁基苯酞对大脑中动脉闭塞大鼠局部脑血流的影响。
Effects of dl-3-n-butylphthalide on regional cerebral blood flow in right middle cerebral artery occlusion rats.
作者信息
Yan C H, Feng Y P, Zhang J T
机构信息
Institute of Materia Medica, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
出版信息
Zhongguo Yao Li Xue Bao. 1998 Mar;19(2):117-20.
AIM
To study the effect of dl-3-n-butylphthalide (NBP) on regional cerebral blood flow (rCBF) in forcal cerebral ischemia rats.
METHODS
In chloral hydrate-anesthetized rat, the proximal portion of right middle cerebral artery (RMCA) was occluded, and H2 needle electrode was implanted in right striatum. rCBF was monitored in striatum using hydrogen clearance method.
RESULTS
Ten min after RMCA occlusion (RMCAO), NBP (5, 10, 20 mg.kg-1 i.p.) markedly increased rCBF to striatum (P < 0.01). When NBP was given i.p. 40 min after RMCAO, the increasing effect on rCBF was also observed (P < 0.05). However, when NBP was injected i.p. 60 min after RMCAO, the increasing effect of NBP on rCBF was not found. In NBP-pretreated (i.p. 40 min before RMCAO) group, rCBF in striatum measured at different time points of 30, 60, 90, 120, 150, and 180 min after RMCAO were increased by 97%, 107%, 136%, 211%, 173%, and 317%, respectively, compared with the percentages of vehicle group. The potency of the effect of Nim (0.5 mg.kg-1 i.p.) was similar to that of NBP (10 mg.kg-1 i.p.).
CONCLUSION
NBP pre-treatment or post-treatment markedly enhanced the rCBF to striatum in RMCAO rats.
目的
研究dl-3-正丁基苯酞（NBP）对局部脑缺血大鼠局部脑血流量（rCBF）的影响。
方法
在水合氯醛麻醉的大鼠中，闭塞右侧大脑中动脉（RMCA）近端，并将H2针电极植入右侧纹状体。采用氢清除法监测纹状体的rCBF。
结果
RMCA闭塞（RMCAO）10分钟后，NBP（5、10、20mg·kg-1腹腔注射）显著增加纹状体的rCBF（P<0.01）。RMCAO后40分钟腹腔注射NBP时，也观察到对rCBF的增加作用（P<0.05）。然而，RMCAO后60分钟腹腔注射NBP时，未发现NBP对rCBF的增加作用。在NBP预处理组（RMCAO前40分钟腹腔注射），RMCAO后30、60、90、120、150和180分钟不同时间点测量的纹状体rCBF分别比溶剂组增加了97%、107%、136%、211%、173%和317%。尼莫地平（0.5mg·kg-1腹腔注射）的作用强度与NBP（10mg·kg-1腹腔注射）相似。
结论
NBP预处理或后处理均可显著提高RMCAO大鼠纹状体的rCBF。
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