López-Botet M, Bellón T
Servicio de Inmunología, Hospital Universitario de la Princesa, Diego de León 62, 28006, Madrid, Spain. mlbotet/
Curr Opin Immunol. 1999 Jun;11(3):301-7. doi: 10.1016/s0952-7915(99)80048-x.
Several recent advances have been made in our understanding of the mechanisms which human natural killer cells recognize MHC class I molecules. Three are of special relevance: the identification of a novel molecule (DAP12) with a key role in the activation pathways; the observation that certain immunoglobulin-like receptors for HLA class I molecules are also utilized by other leucocyte lineages; and the definition of MHC class Ib proteins (i.e. HLA-E and Qa-1b) as specific ligands for the phylogenetically conserved CD94-NKG2 lectin-like receptors.
在我们对人类自然杀伤细胞识别MHC I类分子机制的理解方面，最近取得了一些进展。其中三项特别相关：鉴定出一种在激活途径中起关键作用的新分子（DAP12）；观察到某些HLA I类分子的免疫球蛋白样受体也被其他白细胞谱系所利用；以及将MHC Ib类蛋白（即HLA-E和Qa-1b）定义为系统发育保守的CD94-NKG2凝集素样受体的特异性配体。
