Strässer K, Hurt E
BZH, Biochemie-Zentrum Heidelberg, Germany.
FEBS Lett. 1999 Jun 4;452(1-2):77-81. doi: 10.1016/s0014-5793(99)00537-2.
Eukaryotic cells massively exchange macromolecules (proteins and RNAs) between the nucleus and cytoplasm through the nuclear pore complexes. Whereas a mechanistic picture emerges of how proteins are imported into and exported from the nucleus, less is known about nuclear exit of the different classes of RNAs. However, the yeast Saccharomyces cerevisiae offers an experimental system to study nuclear RNA export in vivo and thus to genetically dissect the different RNA export machineries. In this review, we summarize our current knowledge and recent progress in identifying components involved in nuclear RNA export in yeast.
真核细胞通过核孔复合体在细胞核和细胞质之间大量交换大分子(蛋白质和RNA)。虽然关于蛋白质如何进出细胞核已形成了一个机制图,但对于不同种类RNA的核输出了解较少。然而,酿酒酵母提供了一个在体内研究核RNA输出的实验系统,从而能够对不同的RNA输出机制进行遗传学剖析。在这篇综述中,我们总结了目前关于酵母中参与核RNA输出的组分的认识和近期进展。