St-John W M, Leiter J C
Department of Physiology, Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, NH 03756, USA.
Neurosci Lett. 1999 Jun 4;267(3):206-8. doi: 10.1016/s0304-3940(99)00364-x.
Maternal smoking is a risk factor for the sudden infant death syndrome (SIDS). We hypothesized that pre-natal exposure to nicotine would result in abnormalities of ventilatory activity in newborns. Neonatal rats which had been exposed to nicotine had significantly lower minute ventilation breathing air and hypoxic gas mixtures than did control animals. In both groups, anoxia elicited gasping which was equally effective in restoring eupnea. Maternal exposure to nicotine may result in a reduced metabolic rate and/or chronic hypoventilation in the newborn.
母亲吸烟是婴儿猝死综合征（SIDS）的一个风险因素。我们推测，产前接触尼古丁会导致新生儿通气活动异常。与对照动物相比，接触过尼古丁的新生大鼠在呼吸空气和低氧混合气体时的分钟通气量显著更低。在两组中，缺氧都会引发喘息，这在恢复正常呼吸方面同样有效。母亲接触尼古丁可能会导致新生儿代谢率降低和/或慢性通气不足。
