Vogel U, Frosch M
Institut für Hygiene und Mikrobiologie, University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany.
Mol Microbiol. 1999 Jun;32(6):1133-9. doi: 10.1046/j.1365-2958.1999.01469.x.
Pathogenic Neisseria use a variety of mechanisms to survive the bactericidal action of the complement system. Serum resistance is a crucial virulence factor for the development of severe meningococcal disease, meningococcal meningitis and disseminated gonococcal infection. Furthermore, local inflammation at the site of gonococcal infection exposes the bacteria to moderate concentrations of complement factors. We review current concepts of neisserial serum resistance with emphasis on porins and polysaccharides exposed on the neisserial surface and their interaction with components of normal human serum.
致病性奈瑟菌利用多种机制在补体系统的杀菌作用下存活。血清抗性是严重脑膜炎球菌病、脑膜炎球菌性脑膜炎和播散性淋球菌感染发生的关键毒力因子。此外，淋球菌感染部位的局部炎症使细菌暴露于中等浓度的补体因子中。我们综述了奈瑟菌血清抗性的当前概念，重点关注奈瑟菌表面暴露的孔蛋白和多糖及其与正常人血清成分的相互作用。
