羊流产沙门氏菌灭活疫苗可保护小鼠在受到攻击后不发生流产。

A Salmonella abortusovis inactivated vaccine protects mice from abortion after challenge.

作者信息

Giannati-Stefanou A, Koptopoulos G, Hatzopoulou E, Sarris K

机构信息

National Agricultural Research Foundation, Veterinary Institute of Infectious and Parasitic Diseases, Thessaloniki, Hellas, Greece.

出版信息

Vet Microbiol. 1999 May;66(4):285-90. doi: 10.1016/s0378-1135(99)00023-1.

DOI:10.1016/s0378-1135(99)00023-1

PMID:10384889

Abstract

Two types of Salmonella abortusovis vaccines were prepared, one with aluminium hydroxide (vaccine A) and the other with water in oil (vaccine B) adjuvants. They were compared in a pregnant mouse model, aiming at protecting them from abortions after challenge with a virulent strain of S. abortusovis. The protection for vaccine A was from 74% to 77.6% and that for vaccine B from 71% to 79.6%. Abortions occurred 5-10 days post challenge and S. abortusovis was isolated from all aborted fetuses and from the liver and the spleen of their mothers at the end of the experiment (18 days post challenge). The presence of salmonella in the liver and the spleen of vaccinated non-pregnant but challenged mice was studied in a separate experiment. The bacterium was isolated from one out of 12 vaccinated mice 6 days post challenge as well as from the six controls.

摘要

制备了两种羊流产沙门氏菌疫苗，一种含有氢氧化铝（疫苗A），另一种含有油包水佐剂（疫苗B）。在怀孕小鼠模型中对它们进行了比较，目的是保护它们在受到强毒株羊流产沙门氏菌攻击后不发生流产。疫苗A的保护率为74%至77.6%，疫苗B的保护率为71%至79.6%。攻击后5 - 10天发生流产，在实验结束时（攻击后18天），从所有流产胎儿及其母亲的肝脏和脾脏中分离出羊流产沙门氏菌。在另一个单独的实验中，研究了接种疫苗但未怀孕且受到攻击的小鼠肝脏和脾脏中沙门氏菌的存在情况。在攻击后6天，从12只接种疫苗的小鼠中的1只以及6只对照小鼠中分离出了该细菌。