在氟烷麻醉期间，兰地洛尔可降低犬致心律失常剂量的肾上腺素。

Landiolol decreases a dysrhythmogenic dose of epinephrine in dogs during halothane anesthesia.

作者信息

Takahashi S, Fujii Y, Inomata S, Miyabe M, Toyooka H

机构信息

Department of Anaesthesiology, University of Tsukuba, Institute of Clinical Medicine, Ibaraki, Japan.

出版信息

Can J Anaesth. 1999 Jun;46(6):599-604. doi: 10.1007/BF03013554.

DOI:10.1007/BF03013554

PMID:10391611

Abstract

PURPOSE

To examine the effect of landiolol (ONO-1101), a new ultra-short acting and highly selective beta blocker, on epinephrine-induced ventricular arrhythmias in halothane-anesthetized dogs.

METHODS

We administered five different doses (0, 0.1, 0.5, 1.0, 10 microg x kg(-1) x min(-1)) landiolol and determined the dysrhythmogenic dose of epinephrine (DDE), defined as the smallest dose producing four or more PVCs within 15 sec, at each dose of landiolol and after cessation of infusion.

RESULTS

The control value of DDE during 1.3 MAC halothane anesthesia was 1.26 +/- 0.44 (mean +/- SD) microg x kg(-1) x min(-1) and the corresponding plasma concentration of epinephrine (PCE) was 12.2 +/- 8.3 ng x ml(-1). Concomitant administration of 10 microg x kg(-1) x min(-1) landiolol increased DDE and corresponding PCE (P < 0.05). At 30 min after cessation of landiolol infusion, DDE and corresponding PCE returned to the control values.

CONCLUSIONS

Landiolol, at a dose of 10 microg x kg(-1) x min(-1), has an antiarrhythmic effect on epinephrine-induced ventricular arrhythmias in dogs during anesthesia with halothane.

摘要

目的

研究新型超短效、高选择性β受体阻滞剂兰地洛尔（ONO - 1101）对氟烷麻醉犬肾上腺素诱发室性心律失常的影响。

方法

我们给予五种不同剂量（0、0.1、0.5、1.0、10微克×千克⁻¹×分钟⁻¹）的兰地洛尔，并在每种兰地洛尔剂量给药时及输注停止后，确定肾上腺素致心律失常剂量（DDE），定义为在15秒内产生四个或更多室性早搏的最小剂量。

结果

在1.3 MAC氟烷麻醉期间，DDE的对照值为1.26±0.44（均值±标准差）微克×千克⁻¹×分钟⁻¹，相应的肾上腺素血浆浓度（PCE）为12.2±8.3纳克×毫升⁻¹。同时给予10微克×千克⁻¹×分钟⁻¹的兰地洛尔可使DDE和相应的PCE增加（P<0.05）。在兰地洛尔输注停止30分钟后，DDE和相应的PCE恢复至对照值。