鸟分枝杆菌和副结核分枝杆菌的GroES抗原。
The GroES antigens of Mycobacterium avium and Mycobacterium paratuberculosis.
作者信息
Cobb A J, Frothingham R
机构信息
Veterans Affairs Medical Center, Durham, NC 27705, USA.
出版信息
Vet Microbiol. 1999 Jun 1;67(1):31-5. doi: 10.1016/s0378-1135(99)00019-x.
The GroES antigen provokes a strong immune response in human beings with tuberculosis or leprosy. We cloned and sequenced the Mycobacterium avium and Mycobacterium paratuberculosis GroES genes. M. avium and M. paratuberculosis have identical GroES sequences which differ from other mycobacterial species. This supports the current formal designation of M. paratuberculosis as M. avium subsp. paratuberculosis. Immunodominant epitopes from Mycobacterium tuberculosis GroES are conserved in M. avium, but some Mycobacterium leprae epitopes are distinct. GroES is unlikely to be specific as a serologic or skin test reagent, but may be an appropriate component of a broad mycobacterial vaccine.
格罗ES抗原在患有结核病或麻风病的人类中引发强烈的免疫反应。我们克隆并测序了鸟分枝杆菌和副结核分枝杆菌的格罗ES基因。鸟分枝杆菌和副结核分枝杆菌具有相同的格罗ES序列，这与其他分枝杆菌物种不同。这支持了目前将副结核分枝杆菌正式命名为鸟分枝杆菌副结核亚种。结核分枝杆菌格罗ES的免疫显性表位在鸟分枝杆菌中是保守的，但一些麻风分枝杆菌表位是不同的。格罗ES作为血清学或皮肤试验试剂不太可能具有特异性，但可能是一种广泛的分枝杆菌疫苗的合适成分。
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