秀丽隐杆线虫生殖系的启动：早期生殖细胞中的基因表达调控
Launching the germline in Caenorhabditis elegans: regulation of gene expression in early germ cells.
作者信息
Seydoux G, Strome S
机构信息
Department of Molecular Biology and Genetics, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.
出版信息
Development. 1999 Aug;126(15):3275-83. doi: 10.1242/dev.126.15.3275.
PMID:10393107
Abstract
One hundred years after Weismann's seminal observations, the mechanisms that distinguish the germline from the soma still remain poorly understood. This review describes recent studies in Caenorhabditis elegans, which suggest that germ cells utilize unique mechanisms to regulate gene expression. In particular, mechanisms that repress the production of mRNAs appear to be essential to maintain germ cell fate and viability.
摘要
在魏斯曼做出开创性观察的一百年后，区分生殖细胞和体细胞的机制仍然知之甚少。这篇综述描述了秀丽隐杆线虫的近期研究，这些研究表明生殖细胞利用独特的机制来调控基因表达。特别是，抑制mRNA产生的机制似乎对于维持生殖细胞命运和活力至关重要。
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