轴突萎缩：回缩反应。

Axonal atrophy: the retraction reaction.

作者信息

Bernstein M, Lichtman J W

机构信息

Department of Anatomy and Neurobiology, Box 8108, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110,USA.

出版信息

Curr Opin Neurobiol. 1999 Jun;9(3):364-70. doi: 10.1016/s0959-4388(99)80053-1.

DOI:10.1016/s0959-4388(99)80053-1

PMID:10395581

Abstract

Recent studies indicate that morphological alterations of axon branches that are removed during normal development are similar to those that occur following ablation of postsynaptic cells in adult animals. In both situations, axons retract (rather than degenerate), the calibers of withdrawing axon branches are markedly reduced, and spherical swellings near (or at) the axon terminations appear. The similarity between naturally occurring and target-deprived axon withdrawal suggests that both developing and adult axons withdraw from target cells that no longer provide support.

摘要

最近的研究表明，在正常发育过程中被去除的轴突分支的形态改变，与成年动物中突触后细胞被切除后发生的改变相似。在这两种情况下，轴突都会回缩（而非退化），回缩的轴突分支的直径会显著减小，并且在轴突终末附近（或在轴突终末处）会出现球形膨大。自然发生的轴突回缩与靶剥夺诱导的轴突回缩之间的相似性表明，发育中的轴突和成年轴突都会从不再提供支持的靶细胞中回缩。