Matthews G
Department of Neurobiology and Behavior, State University of New York, Stony Brook 11794-5230, USA.
Vision Res. 1999 Jul;39(15):2469-76. doi: 10.1016/s0042-6989(98)00249-1.
Giant synaptic terminals of goldfish bipolar neurons allow direct studies of presynaptic mechanisms underlying neurotransmitter release and its modulation. Calcium influx via L-type calcium channels of the terminal triggers synaptic vesicle exocytosis, which can be monitored in isolated terminals by means of the associated changes in membrane capacitance. Information about the kinetics and calcium dependence of synaptic exocytosis has been obtained from capacitance measurements in these ribbon-type synaptic terminals.
金鱼双极神经元的巨大突触终末使得对神经递质释放及其调节的突触前机制进行直接研究成为可能。通过终末的L型钙通道的钙内流触发突触小泡胞吐作用,这可以通过膜电容的相关变化在分离的终末中进行监测。关于突触胞吐作用的动力学和钙依赖性的信息已从这些带状突触终末的电容测量中获得。