Robinson T E, Kolb B
Department of Psychology and Neuroscience Program, The University of Michigan, Ann Arbor, Michigan 48109, USA.
Synapse. 1999 Aug;33(2):160-2. doi: 10.1002/(SICI)1098-2396(199908)33:2<160::AID-SYN6>3.0.CO;2-S.
Rats were given repeated injections of 10 mg/kg of morphine and were then left undisturbed for 24-25 days before their brains were processed for Golgi-Cox staining. Prior exposure to morphine decreased the complexity of dendritic branching and the number of dendritic spines on medium spiny neurons in the shell of the nucleus accumbens and on pyramidal cells in the prefrontal and parietal cortex. It is suggested that some of the long-term behavioral consequences of repeated exposure to morphine may be due to its ability to reorganize patterns of synaptic connectivity in the forebrain.
给大鼠反复注射10毫克/千克的吗啡，然后让它们在24 - 25天内不受干扰，之后对其大脑进行高尔基-考克斯染色处理。先前接触吗啡会降低伏隔核壳中的中等棘状神经元以及前额叶和顶叶皮质中的锥体细胞的树突分支复杂性和树突棘数量。有人认为，反复接触吗啡的一些长期行为后果可能是由于其能够重组前脑的突触连接模式。
