Kristensen P
J Membr Biol. 1978;40 Spec No:167-85. doi: 10.1007/BF02026004.
Amiloride is found to inhibit chloride exchange diffusion in toad skin and passive chloride transport in frog skin. In both tissues, chloride transport is reactivated by substituting with KCl-Ringer's on the inside, so the effect of amiloride on chloride transport is secondary to its well-known inhibition of sodium transport. Removal of chloride from the outside bathing solution inhibits chloride outflux in both tissues. This is easy to explain in the case of the toad skin where chloride transport under short-circuit conditions occurs as exchange diffusion. In the frog skin this transeffect indicates that the chloride concentration at a location very near the outer surface is of significance for chloride permeability. The possibility is discussed that the chloride concentration in the outward facing membrane, or in compartments near to it, regulates chloride fluxes across frog skin.
发现氨氯吡咪可抑制蟾蜍皮肤中的氯交换扩散以及青蛙皮肤中的被动氯转运。在这两种组织中，通过用内部的氯化钾 - 林格氏液替代可使氯转运重新激活，因此氨氯吡咪对氯转运的作用继发于其对钠转运的著名抑制作用。从外部浴液中去除氯会抑制两种组织中的氯外流。在蟾蜍皮肤的情况下这很容易解释，因为在短路条件下氯转运以交换扩散的形式发生。在青蛙皮肤中，这种跨效应表明非常靠近外表面处的氯浓度对氯通透性具有重要意义。文中讨论了向外的膜中或其附近隔室中的氯浓度调节青蛙皮肤氯通量的可能性。
