单次注射β-1b干扰素后出现致死性毛细血管渗漏综合征。

Lethal capillary leak syndrome after a single administration of interferon beta-1b.

作者信息

Schmidt S, Hertfelder H J, von Spiegel T, Hering R, Harzheim M, Lassmann H, Deckert-Schlüter M, Schlegel U

机构信息

Department of Neurology, University of Bonn, Germany.

出版信息

Neurology. 1999 Jul 13;53(1):220-2. doi: 10.1212/wnl.53.1.220.

DOI:10.1212/wnl.53.1.220

PMID:10408566

Abstract

Interferon beta-1b (IFNbeta-1b) is a potent immunomodulatory drug in the treatment of MS. We report a lethal capillary leak syndrome after the administration of IFNbeta-1b in a patient with disseminated white matter disease, monoclonal gammopathy, and acquired C1 inhibitor (C1-INH) deficiency. IFNbeta-1b may cause a transient release of proinflammatory cytokines finally resulting in an uninhibited activation of the complement cascade in patients with C1-INH deficiency.

摘要

干扰素β-1b（IFNβ-1b）是治疗多发性硬化症的一种强效免疫调节药物。我们报告了1例患有弥漫性白质病、单克隆丙种球蛋白病和获得性C1抑制物（C1-INH）缺乏症的患者在使用IFNβ-1b后发生致命性毛细血管渗漏综合征。IFNβ-1b可能导致促炎细胞因子的短暂释放，最终在C1-INH缺乏症患者中导致补体级联反应的无抑制激活。