Waldner M, Hertle L, Roth S
Department of Urology, University of Münster, Germany.
J Urol. 1999 Aug;162(2):323-6.
Whether antireflux implantation techniques are necessary in adults who undergo ileal ureteral substitution is controversial. We prospectively evaluated the correlation between reflux and renal function in 19 patients who underwent ileal ureteral substitution with no antireflux implantation technique.
Followup included clinical evaluation, serum creatinine, blood gasses, excretory urogram, cystogram and dynamic selective renographic clearance on technetium mercaptotriglycine renal scans. All patients were followed for a minimum of 4 years except 2 who died 26 and 43 months postoperatively. Mean followup was 57 months (range 48 to 72).
Despite reflux, renal scans indicated a significant increase in renal function in all patients. Vesico-ileal reflux was present in 9 cases and reflux in the renal pelvis occurred in only 3. Reflux occurred in only 3 of 10 patients with ileal segments longer than 15 cm., and did not reach the renal pelvis.
Reflux appears to have no detrimental effect on renal function in adults with ileal ureters and, therefore, an antireflux procedure is unnecessary. In addition, an ileal segment longer than 15 cm. appears to safeguard the renal pelvis against visible reflux stemming from pro-grade intestinal peristalsis.
对于接受回肠代输尿管术的成人患者,抗反流植入技术是否必要存在争议。我们前瞻性评估了19例未采用抗反流植入技术接受回肠代输尿管术患者的反流与肾功能之间的相关性。
随访包括临床评估、血清肌酐、血气分析、排泄性尿路造影、膀胱造影以及锝-巯基丁二酸肾扫描动态选择性肾图清除率。除2例分别于术后26个月和43个月死亡外,所有患者至少随访4年。平均随访时间为57个月(范围48至72个月)。
尽管存在反流,但肾扫描显示所有患者的肾功能均显著提高。9例出现膀胱-回肠反流,仅3例出现肾盂反流。在10例回肠段长度超过15 cm的患者中,仅3例出现反流,且未累及肾盂。
反流似乎对回肠代输尿管的成人患者的肾功能无不利影响,因此抗反流手术并无必要。此外,回肠段长度超过15 cm似乎可保护肾盂免受顺行性肠道蠕动引起的明显反流影响。