Shustrova I V, Chebykina L I
Severtzov Institute of Ecology and Evolution, Russian Academy of Sciences, Moscow, Russia.
Genetika. 1999 Apr;35(4):556-8.
Data on molecular genetic analysis of the novel wild-type twMP1 haplotype found in a population of Mus domesticus from Peru are presented. Complementation attribution of the novel haplotype as well as fertility of heterozygotes and transmission ratio distortion (TRD) of the t-carrying chromosome in the progeny of the heterozygous males were studied. Molecular analysis was carried out by means of blot hybridization with the four t-specific probes (Tu48, Tu66, Tu119, and Tu122). Comparison of the results obtained with the data on the structure and properties of the t complexes permitted conclusion on the complete lethality of the haplotype described.
本文呈现了在来自秘鲁的家鼠群体中发现的新型野生型twMP1单倍型的分子遗传学分析数据。研究了该新型单倍型的互补归属以及杂合子的育性和杂合雄性后代中携带t染色体的传递比率畸变(TRD)。通过与四种t特异性探针(Tu48、Tu66、Tu119和Tu122)进行印迹杂交进行分子分析。将所得结果与t复合体的结构和特性数据进行比较,得出了所描述单倍型完全致死的结论。