顶复门生物的质体作为药物靶点。

Apicomplexan plastids as drug targets.

作者信息

McFadden G I, Roos D S

机构信息

Plant Cell Biology Research Center, School of Botany, University of Melbourne, Parkville, VIC 3052, Australia.

出版信息

Trends Microbiol. 1999 Aug;7(8):328-33. doi: 10.1016/s0966-842x(99)01547-4.

DOI:10.1016/s0966-842x(99)01547-4

PMID:10431206

Abstract

Prokaryotic metabolic pathways in the relict plastid of apicomplexan parasites make this organelle a promising target for drug development. The parasiticidal activity of several herbicides and antibacterial antibiotics is suspected to be a result of their ability to inhibit key plastid activities.

摘要

顶复门寄生虫残留质体中的原核生物代谢途径使这个细胞器成为药物开发的一个有前景的靶点。几种除草剂和抗菌抗生素的杀寄生虫活性被怀疑是它们抑制关键质体活性能力的结果。