听神经瘤生长：对治疗选择的影响。

Acoustic tumor growth: implications for treatment choices.

作者信息

Fucci M J, Buchman C A, Brackmann D E, Berliner K I

机构信息

House Ear Clinic, Los Angeles, California, USA.

出版信息

Am J Otol. 1999 Jul;20(4):495-9.

PMID:10431892

Abstract

BACKGROUND

Knowledge of acoustic neuroma (AN) growth is essential for treatment planning.

METHODS

A retrospective analysis of 119 patients with AN (mean age, 65 years; range, 37-84 years) followed with interval magnetic resonance imagings (MRIs) was performed. Change in maximum tumor dimension as a function of follow-up period was analyzed.

RESULTS

Overall, maximum tumor dimension increased >2 mm in only 30% of patients. Of those that grew, the mean growth rate was 3.8 mm/year (maximum, 25 mm/year). Age, gender, and laterality did not predict growth. Most tumors that grew (86.1 %) were <20 mm at presentation. However, tumors >20 mm were statistically more likely to grow (71%, p =0.028).

CONCLUSIONS

Most ANs followed with periodic MRIs do not grow. Available clinical information usually cannot predict growth. Serial MRIs are advocated for all patients treated with observation.

摘要

背景

了解听神经瘤（AN）的生长情况对于治疗方案的制定至关重要。

方法

对119例听神经瘤患者（平均年龄65岁；范围37 - 84岁）进行回顾性分析，这些患者接受了定期的磁共振成像（MRI）检查。分析肿瘤最大直径随随访时间的变化情况。

结果

总体而言，仅30%的患者肿瘤最大直径增加超过2 mm。在肿瘤生长的患者中，平均生长速度为3.8 mm/年（最大为25 mm/年）。年龄、性别和肿瘤位置均不能预测肿瘤生长。大多数生长的肿瘤（86.1%）在初诊时直径小于20 mm。然而，直径大于20 mm的肿瘤在统计学上更有可能生长（71%，p = 0.028）。