新型氟化L-核苷；合成及抗病毒活性。
New classes of fluorinated L-nucleosides; synthesis and antiviral activity.
作者信息
Lee K, Choi Y, Hong J H, Schinazi R F, Chu C K
机构信息
Department of Parmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens 30602, USA.
出版信息
Nucleosides Nucleotides. 1999 Apr-May;18(4-5):537-40. doi: 10.1080/15257779908041489.
PMID:10432644
Abstract
The synthesis of 3'-fluorinated apionucleosides 7 and 2'-fluoro-2',3'-unsaturated L-nucleosides 8 via common synthon, 2-fluoro-butenolide 2, has been described. Among the newly synthesized nucleosides, L-2'-F-d4C, L-2'-F-d4FC and L-2'-F-d4A exhibit significant anti-HIV and anti-HBV activities.
摘要
已经描述了通过共同合成子2-氟丁烯内酯2合成3'-氟化阿皮核苷7和2'-氟-2',3'-不饱和L-核苷8的方法。在新合成的核苷中，L-2'-F-d4C、L-2'-F-d4FC和L-2'-F-d4A表现出显著的抗HIV和抗HBV活性。
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