一种新型抗肿瘤核苷，1-(3-C-乙炔基-β-D-核糖-戊呋喃糖基)胞嘧啶（ECyd），是RNA合成的有效抑制剂。
A new antitumor nucleoside, 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine (ECyd), is a potent inhibitor of RNA synthesis.
作者信息
Matsuda A, Fukushima M, Wataya Y, Sasaki T
机构信息
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
出版信息
Nucleosides Nucleotides. 1999 Apr-May;18(4-5):811-4. doi: 10.1080/15257779908041568.
PMID:10432683
Abstract
The antitumor activity, metabolism, and mechanism of action of a newly developed antitumor nucleoside, 1-(3-C-Ethynyl-beta-D-ribo-pentofuranosyl)cytosine (ECyd) are described.
摘要
描述了一种新开发的抗肿瘤核苷1-(3-C-乙炔基-β-D-核糖-戊呋喃糖基)胞嘧啶（ECyd）的抗肿瘤活性、代谢及作用机制。
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