CycloSal-2'-ara(ribo)-fluoro-2',3'-dideoxyadenosine monophosphates--an effort to solve the structure-activity relationship of 2'-fluoro-ddA.
作者信息
Meier C, Knispel T, Marquez V E, De Clercq E, Balzarini J
机构信息
Institut für Organische Chemie, Universität Hamburg, Germany.
出版信息
Nucleosides Nucleotides. 1999 Apr-May;18(4-5):907-12. doi: 10.1080/15257779908041598.
PMID:10432708
Abstract
Novel lipophilic cycloSal-triesters 3 and 4 from the ara- and ribo-configurated 2'-fluorinated ddAs 1 and 2, respectively, were prepared. The title compounds 3 and 4 delivered the corresponding monophosphates and thus, increasing the bioactivity or convert a formerly inactive compound into a RT inhibitor.
摘要
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