Wirén M, Adrian T E, Arnelo U, Permert J, Staab P, Larsson J
Department of Surgery, Faculty of Health Sciences, University of Linköping, Sweden.
Dig Surg. 1999;16(3):197-203. doi: 10.1159/000018727.
Intestinal resection stimulates the synthesis and release of gastrointestinal peptides that regulate the growth and adaptation of the mucosa. Luminal nutrients are necessary for optimal proliferation and glutamine is the preferential nutrient to the small bowel. The interplay between glutamine and regulatory peptides could be important in treating short bowel syndrome.
63 Sprague-Dawley rats were divided into 3 groups: resection; transection, or controls. After intestinal resection animals were orally fed either a diet without glutamine or a glutamine-supplemented diet for 2 days. Transected animals and controls without prior surgery were fed the same two diets. Epidermal growth factor (EGF), transforming growth factor-alpha, insulin-like growth factors I and II (IGF-I and IGF-II), peptide YY (PYY), and enteroglucagon were analyzed in mucosa from the proximal jejunum, distal ileum as well as in portal plasma when the animals were euthanized 72 h after surgery.
Intestinal resection resulted in an early increase in portal plasma concentrations of PYY, EGF, enteroglucagon, and mucosal IGF-II and EGF content that were significant in glutamine-treated animals. Glutamine significantly increased PYY in portal blood after resection (p < 0.05).
Glutamine could be of importance for the functional adaptation of residual small bowel mucosa by increasing PYY release.
肠道切除会刺激胃肠道肽的合成与释放，这些肽可调节黏膜的生长与适应性。腔内营养物质对最佳增殖是必需的，谷氨酰胺是小肠的优先营养物质。谷氨酰胺与调节肽之间的相互作用在治疗短肠综合征中可能很重要。
63只Sprague-Dawley大鼠分为3组：切除组；横断组，或对照组。肠道切除术后，给动物口服不含谷氨酰胺的饮食或补充谷氨酰胺的饮食2天。横断组动物和未进行过手术的对照组给予相同的两种饮食。在术后72小时对动物实施安乐死时，分析空肠近端、回肠远端黏膜以及门静脉血浆中的表皮生长因子（EGF）、转化生长因子-α、胰岛素样生长因子I和II（IGF-I和IGF-II）、肽YY（PYY）和肠高血糖素。
肠道切除导致门静脉血浆中PYY、EGF、肠高血糖素以及黏膜IGF-II和EGF含量早期增加，这在谷氨酰胺处理的动物中很显著。切除术后，谷氨酰胺显著增加门静脉血中的PYY（p < 0.05）。
谷氨酰胺可能通过增加PYY释放对残余小肠黏膜的功能适应性具有重要意义。
