肝脾γδ T细胞淋巴瘤中7号染色体等臂染色体和8号染色体三体的一致性：通过荧光原位杂交检测一名儿科患者脾脏触片标本

Consistency of isochromosome 7q and trisomy 8 in hepatosplenic gammadelta T-cell lymphoma: detection by fluorescence In situ hybridization of a splenic touch-preparation from a pediatric patient.

作者信息

Coventry S, Punnett H H, Tomczak E Z, Casher D, Koehler M, Borowitz M J, Griffin C A, de Chadarévian J P

机构信息

Department of Pathology, St. Christopher's Hospital for Children, Erie Avenue at Front Street, Philadelphia, PA 19134, USA.

出版信息

Pediatr Dev Pathol. 1999 Sep-Oct;2(5):478-83. doi: 10.1007/s100249900152.

DOI:10.1007/s100249900152

PMID:10441626

Abstract

Hepatosplenic gamma-delta (gammadelta) T-cell lymphoma is a rare but increasingly recognized lymphoid malignancy predominantly affecting young adult males. It is not well appreciated in the pediatric population. We report the third case of this aggressive lymphoma in a child as well as additional support for the consistency of the recently discovered cytogenetic abnormalities, isochromosome 7q and trisomy 8, which in this case were documented using fluorescence in situ hybridization (FISH) of a touch-preparation of the spleen.

摘要

肝脾γδ（γδ）T细胞淋巴瘤是一种罕见但越来越被认识到的淋巴恶性肿瘤，主要影响年轻成年男性。在儿科人群中对此病的认识不足。我们报告了该侵袭性淋巴瘤在儿童中的第三例病例，并为最近发现的细胞遗传学异常——7号染色体长臂等臂染色体和8号染色体三体性的一致性提供了更多支持，在本病例中，通过脾脏触片的荧光原位杂交（FISH）记录了这些异常。