Knobloch W, Hauser E, Niehues R, Schiele T, Metzger G, Jacksch R
Klinik für Kardiologie, St.-Vincenz-Krankenhaus, Akademisches Lehrkrankenhaus der Gesamthochschule Essen.
Z Kardiol. 1999 Jun;88(6):448-53. doi: 10.1007/s003920050308.
The coincidence of aortic valve stenosis and cryptogenic gastrointestinal bleeding usually from angiodysplasia of the cecum and ascending colon has been called Heyde syndrome. The pathophysiologic link between both remains unclear and may be due to subtle changes in plasmatic coagulation. There are some statistic and numerous casuistic reports, and recently the existence of the syndrome has been questioned. We describe two cases of aortic valve stenosis and cryogenic gastrointestinal bleeding in which bleeding subsided after replacement with a bioprosthesis. We give an overview of the current literature.