巩膜外斑块放疗与质子束放疗治疗脉络膜黑色素瘤的比较。

Comparison of episcleral plaque and proton beam radiation therapy for the treatment of choroidal melanoma.

作者信息

Wilson M W, Hungerford J L

机构信息

St. Bartholomew's Hospital, London, England.

出版信息

Ophthalmology. 1999 Aug;106(8):1579-87. doi: 10.1016/S0161-6420(99)90456-6.

DOI:10.1016/S0161-6420(99)90456-6

PMID:10442907

Abstract

PURPOSE

To compare the efficacy of iodine-125 (125I) and ruthenium-106 (106Ru) episcleral plaque radiation therapy and proton beam radiation therapy (PBRT) in the treatment of choroidal melanoma.

DESIGN

A retrospective, nonrandomized comparative study.

METHODS

Charts of patients treated with 125I, 106Ru, and PBRT for choroidal melanoma between January 1988 and June 1996 at St. Bartholomew's Hospital and Moorfields Eye Hospitals were reviewed.

MAIN OUTCOME MEASURE

Local control of choroidal melanomas after 125I, 106Ru, or PBRT.

RESULTS

A total of 597 patients were identified (125I = 190, 106Ru = 140, PBRT = 267). Patients treated with 106Ru had a significantly greater risk of local tumor recurrence than did patients treated with either 125I (P = 0.0133; confidence interval [CI], 1.26-7.02; risk ratio, 2.97) or PBRT (P = 0.0097; CI, 1.30-6.66; risk ratio, 2.94). A stepwise Cox proportional hazard model found maximal basal diameter to be a significant covariate (P = 0.0033).

CONCLUSION

Patients treated with 106Ru had a significantly greater risk of local tumor recurrence than did those patients treated with either 125I or PBRT.

摘要

目的

比较碘-125（¹²⁵I）、钌-106（¹⁰⁶Ru）巩膜外斑块放射治疗和质子束放射治疗（PBRT）在脉络膜黑色素瘤治疗中的疗效。

设计

一项回顾性、非随机对照研究。

方法

回顾了1988年1月至1996年6月期间在圣巴塞洛缪医院和摩尔菲尔德眼科医院接受¹²⁵I、¹⁰⁶Ru和PBRT治疗的脉络膜黑色素瘤患者的病历。

主要观察指标

¹²⁵I、¹⁰⁶Ru或PBRT治疗后脉络膜黑色素瘤的局部控制情况。

结果

共纳入597例患者（¹²⁵I组190例，¹⁰⁶Ru组140例，PBRT组267例）。接受¹⁰⁶Ru治疗的患者局部肿瘤复发风险显著高于接受¹²⁵I治疗的患者（P = 0.0133；置信区间[CI]，1.26 - 7.02；风险比，2.97）或接受PBRT治疗的患者（P = 0.0097；CI，1.30 - 6.66；风险比，2.94）。逐步Cox比例风险模型发现最大基底直径是一个显著的协变量（P = 0.0033）。