Koscielniak-Nielsen Z J, Rotbøll Nielsen P, Sørensen T, Stenør M
Department of Anaesthesia and Intensive Care, National University Hospital, Rigshospitalet AN 4132, Copenhagen, Denmark.
Can J Anaesth. 1999 Jul;46(7):658-64. doi: 10.1007/BF03013954.
To compare anesthetic time, success rate and adverse effects of axillary block by single or multiple injections of local anesthetic.
Two groups of patients were studied. In group T (targeted injections, n = 53) the four terminal nerves were located by electrical stimulation, and anesthetized with 5 ml mepivacaine 1% with epinephrine 5 microg x ml(-1) (MEPE). In group S (single injection, n = 53) 80 mL MEPE 1% were injected into the neurovascular sheath, transarterially or after eliciting paresthesia. Patchy blocks were supplemented after 30 min. The patient was ready for surgery when analgesia was present in all areas distal to the elbow.
The block was complete at 11 min (6-15) in Group T and 7 min (5-13) in group S, P<0.01. Supplementation was required in 46% in group S compared with 13% in group T P<0.001: anesthesia time was 32 min (19-52) in group T, and 39 min (16-58) in group S, P = 0.02. The average doses of MEPE were 3.5 mg x kg(-1) (2.4-5.6) in T group and 12.0 mg x kg(-1) (8.9-16.4), in S group. However, 22% of patients in group T and 4% in group S reported tourniquet pain, P = 0.02. Paresthesia was elicited in 42% of patients in group S and 8% in group T, P<0.001.
Small targeted injections of MEPE reduce total anesthetic time, give better spread of analgesia in the hand and forearm, and may be safer than a single large injection.
比较单次或多次注射局部麻醉药行腋路阻滞的麻醉时间、成功率及不良反应。
对两组患者进行研究。T组(靶向注射组,n = 53)通过电刺激定位四条终末神经,并用5 ml含肾上腺素5 μg/ml的1%甲哌卡因(MEPE)进行麻醉。S组(单次注射组,n = 53)将80 ml 1%的MEPE经动脉或在引出异感后注入神经血管鞘。30分钟后补充局部阻滞。当肘部以下所有区域均出现镇痛时,患者准备好接受手术。
T组阻滞在11分钟(6 - 15分钟)时完成,S组在7分钟(5 - 13分钟)时完成,P<0.01。S组46%的患者需要补充麻醉,而T组为13%,P<0.001;T组麻醉时间为32分钟(19 - 52分钟),S组为39分钟(16 - 58分钟),P = 0.02。T组MEPE的平均剂量为3.5 mg/kg(2.4 - 5.6),S组为12.0 mg/kg(8.9 - 16.4)。然而,T组22%的患者和S组4%的患者报告有止血带疼痛,P = 0.02。S组42%的患者引出了异感,T组为8%,P<0.001。
小剂量靶向注射MEPE可减少总麻醉时间,在手和前臂产生更好的镇痛效果,且可能比单次大剂量注射更安全。