青少年孕期饮酒：对新生儿结局的影响。
Prenatal alcohol use among teenagers: effects on neonatal outcomes.
作者信息
Cornelius M D, Goldshmidt L, Taylor P M, Day N L
机构信息
Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA.
出版信息
Alcohol Clin Exp Res. 1999 Jul;23(7):1238-44. doi: 10.1111/j.1530-0277.1999.tb04284.x.
BACKGROUND
This longitudinal study examines the effects of alcohol use during pregnancy on the growth and gestational age at birth of 413 offspring of adolescents.
METHODS
Data were collected during 1990 to 1994. The adolescents were from a prenatal clinic in Pittsburgh, PA. They were interviewed at mid-pregnancy and at delivery to obtain information on alcohol and other substance use before and during pregnancy. Infants were examined 24 to 36 hr after birth.
RESULTS
The average maternal age was 16.3 (12-18) years; 68% were African American. Prenatal exposure to alcohol during the second trimester was significantly related to decreases in head circumference, birthweight, and chest circumference. There was also a significant relationship between alcohol exposure in each trimester and lower Apgar scores. All of the analyses controlled for other prenatal substance use and covariates of drinking during pregnancy.
CONCLUSION
Prenatal alcohol exposure is associated with decreases in fetal growth and in APGAR scores in the offspring of adolescents.
背景
这项纵向研究调查了孕期饮酒对413名青少年后代出生时生长发育及胎龄的影响。
方法
数据收集于1990年至1994年期间。这些青少年来自宾夕法尼亚州匹兹堡的一家产前诊所。在孕期中期和分娩时对他们进行访谈，以获取孕期前后酒精及其他物质使用情况的信息。婴儿在出生后24至36小时接受检查。
结果
母亲的平均年龄为16.3（12 - 18）岁；68%为非裔美国人。孕中期接触酒精与头围、出生体重和胸围的降低显著相关。每个孕期接触酒精与较低的阿氏评分之间也存在显著关系。所有分析均对其他产前物质使用情况及孕期饮酒的协变量进行了控制。
结论
孕期接触酒精与青少年后代的胎儿生长发育及阿氏评分降低有关。
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