恶性疟原虫3号染色体的完整核苷酸序列。
The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum.
作者信息
Bowman S, Lawson D, Basham D, Brown D, Chillingworth T, Churcher C M, Craig A, Davies R M, Devlin K, Feltwell T, Gentles S, Gwilliam R, Hamlin N, Harris D, Holroyd S, Hornsby T, Horrocks P, Jagels K, Jassal B, Kyes S, McLean J, Moule S, Mungall K, Murphy L, Oliver K, Quail M A, Rajandream M A, Rutter S, Skelton J, Squares R, Squares S, Sulston J E, Whitehead S, Woodward J R, Newbold C, Barrell B G
机构信息
Pathogen Sequencing Unit, Sanger Centre, Wellcome Trust Genome Campus, Hinxton, UK.
出版信息
Nature. 1999 Aug 5;400(6744):532-8. doi: 10.1038/22964.
Analysis of Plasmodium falciparum chromosome 3, and comparison with chromosome 2, highlights novel features of chromosome organization and gene structure. The sub-telomeric regions of chromosome 3 show a conserved order of features, including repetitive DNA sequences, members of multigene families involved in pathogenesis and antigenic variation, a number of conserved pseudogenes, and several genes of unknown function. A putative centromere has been identified that has a core region of about 2 kilobases with an extremely high (adenine + thymidine) composition and arrays of tandem repeats. We have predicted 215 protein-coding genes and two transfer RNA genes in the 1,060,106-base-pair chromosome sequence. The predicted protein-coding genes can be divided into three main classes: 52.6% are not spliced, 45.1% have a large exon with short additional 5' or 3' exons, and 2.3% have a multiple exon structure more typical of higher eukaryotes.
对恶性疟原虫3号染色体的分析以及与2号染色体的比较，突显了染色体组织和基因结构的新特征。3号染色体的亚端粒区域呈现出保守的特征顺序，包括重复DNA序列、参与发病机制和抗原变异的多基因家族成员、一些保守的假基因以及几个功能未知的基因。已鉴定出一个推定的着丝粒，其核心区域约2千碱基，具有极高的（腺嘌呤 + 胸腺嘧啶）组成以及串联重复序列阵列。在1,060,106碱基对的染色体序列中，我们预测了215个蛋白质编码基因和两个转运RNA基因。预测的蛋白质编码基因可分为三大类：52.6% 不进行剪接，45.1% 有一个大的外显子以及短的额外5' 或3' 外显子，2.3% 具有更典型的高等真核生物的多个外显子结构。
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