黏膜类天疱疮临床亚组中的免疫球蛋白A抗体反应。
The immunoglobulin A antibody response in clinical subsets of mucous membrane pemphigoid.
作者信息
Egan C A, Taylor T B, Meyer L J, Petersen M J, Zone J J
机构信息
Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA.
出版信息
Dermatology. 1999;198(4):330-5. doi: 10.1159/000018170.
BACKGROUND
Mucous membrane pemphigoid (MMP) is an immunobullous disease. In MMP there is frequently a mixed antibody response with the presence of IgA and/or IgG antibodies directed toward basement membrane zone antigens. The IgG antibody response in MMP has been studied, but the antigens to which the IgA antibodies react have not been studied.
OBJECTIVE
To determine the IgA autoantibody reactivity profiles in patients with MMP.
METHODS
Patients who had both ocular and oral MMP were compared with patients who had ocular or oral MMP and with patients who had cutaneous linear IgA disease (LABD) by Western immunoblot studies.
RESULTS
Five of 15 MMP patients and 1 of 5 LABD patients had IgA antibodies reactive with the 180-kD bullous pemphigoid antigen. Seven of 15 MMP patients had IgA antibodies reactive with the 97-kD LABD antigen.
CONCLUSION
Major antigens in IgA MMP are the 180-kD bullous pemphigoid antigen and the 97-kD LABD antigen.
背景
黏膜类天疱疮（MMP）是一种免疫性大疱性疾病。在MMP中，经常存在混合抗体反应，同时存在针对基底膜区抗原的IgA和/或IgG抗体。MMP中的IgG抗体反应已得到研究，但IgA抗体所反应的抗原尚未得到研究。
目的
确定MMP患者的IgA自身抗体反应谱。
方法
通过蛋白质免疫印迹研究，将患有眼部和口腔MMP的患者与患有眼部或口腔MMP的患者以及患有皮肤线状IgA疾病（LABD）的患者进行比较。
结果
15例MMP患者中有5例以及5例LABD患者中有1例具有与180-kD大疱性类天疱疮抗原反应的IgA抗体。15例MMP患者中有7例具有与97-kD LABD抗原反应的IgA抗体。
结论
IgA MMP中的主要抗原是180-kD大疱性类天疱疮抗原和97-kD LABD抗原。
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