Huber P
CEA, Département de Biologie Moléculaire et Structurale, Grenoble, France.
J Soc Biol. 1999;193(2):181-7.
Endothelial cell-cell junctions are required for integrity of the vascular system. Similar to that of epithelial cells, the interendothelial cleft contains tight, adherens and gap junctions, and the newly-defined complexus adherentes. In the past few years, the molecular components of these organelles were identified as well as their mutual interactions. These data deciphered the complex link between the cell membrane and the cytoskeleton. The contribution of these junctions in vessel formation and permeability is discussed in this review.
内皮细胞间连接对于血管系统的完整性至关重要。与上皮细胞类似,内皮细胞间裂隙包含紧密连接、黏附连接、缝隙连接以及新定义的复合黏附连接。在过去几年中,这些细胞器的分子成分及其相互作用已被确定。这些数据揭示了细胞膜与细胞骨架之间的复杂联系。本综述讨论了这些连接在血管形成和通透性中的作用。