辛伐他汀对主动脉狭窄大鼠左心室肥厚及功能的影响。

Effects of simvastatin on left ventricular hypertrophy and function in rats with aortic stenosis.

作者信息

Luo J D, Zhang W W, Zhang G P, Liu X H, Guan J X

机构信息

Department of Pharmacology, Guangzhou Medical College, China.

出版信息

Zhongguo Yao Li Xue Bao. 1999 Apr;20(4):345-8.

PMID:10452122

Abstract

AIM

To investigate the effects of simvastatin (Sim) on left ventricular hypertrophy in rats with pressure-overload cardiac hypertrophy.

METHODS

The left ventricular hypertrophy (LVH) of rats was induced by partly occluding abdominal aorta below right renal artery. The rats were given i.g. Sim (1.8 and 3.6 mg.kg-1.d-1) for 8 wk. Three days after operation, left ventricular function was measured. Then the left ventricle (LV) + septum and the right ventricle (RV) were weighed. Hydroxyproline content of LV was measured.

RESULTS

Eight weeks later, in the LVH group, LV weight (LVW), LVW/body weight (BW), LVW/RV weight (RVW), LV ending diastolic pressure (LVEDP), and hydroxyproline content increased by 36%, 51%, 28%, 92%, and 23%, respectively (all P < 0.01) compared with the sham group. LV + dp/dtmax and -dp/dtmax decreased by 39.2% and 39.4% (all P < 0.01). After the rats were given i.g. Sim 3.6 mg.kg-1.d-1, LVW, LVW/BW, LVW/RVW, left ventricle ending diastolic pressure (LVEDP), and hydroxyproline content decreased by 22%, 21%, 23%, 24%, and 11% compared with LVH group (all P < 0.01), LV + dp/dtmax and -dp/dtmax increased by 60% and 32% (all P < 0.01).

CONCLUSION

Sim inhibited development of LV hypertrophy and improved LV function in rats with aortic stenosis.

摘要

目的

研究辛伐他汀（Sim）对压力超负荷性心肌肥厚大鼠左心室肥厚的影响。

方法

通过部分结扎右肾动脉下方的腹主动脉诱导大鼠左心室肥厚。大鼠经口给予Sim（1.8和3.6mg·kg-1·d-1），持续8周。术后3天，测量左心室功能。然后称量左心室（LV）+室间隔和右心室（RV）的重量。测量左心室羟脯氨酸含量。

结果

8周后，与假手术组相比，左心室肥厚组的左心室重量（LVW）、LVW/体重（BW）、LVW/RV重量（RVW）、左心室舒张末期压力（LVEDP）和羟脯氨酸含量分别增加了36%、51%、28%、92%和23%（均P<0.01）。LV + dp/dtmax和 -dp/dtmax分别降低了39.2%和39.4%（均P<0.01）。大鼠经口给予3.6mg·kg-1·d-1的Sim后，与左心室肥厚组相比，LVW、LVW/BW、LVW/RVW、左心室舒张末期压力（LVEDP）和羟脯氨酸含量分别降低了22%、21%、23%、24%和11%（均P<0.01），LV + dp/dtmax和 -dp/dtmax分别增加了60%和32%（均P<0.01）。