Dasgupta A, Rice R, Mascha E, Litaker D, Stoller J K
Department of Pulmonary and Critical Care Medicine, Cleveland Clinic Foundation, OH 44195, USA.
Chest. 1999 Aug;116(2):447-55. doi: 10.1378/chest.116.2.447.
In the context that special weaning units have been advocated as effective alternatives to the ICU for weaning selected patients, we initiated a Respiratory Special Care Unit (ReSCU) at the Cleveland Clinic Hospital in August 1993. The goals of the ReSCU were the following: (1) to wean ventilator-dependent patients when possible; and (2) when weaning was not possible, to optimize patient and family instruction for patients going home with ventilatory support. This study presents our 4-year experience with 212 patients managed in the ReSCU and analyzes clinical features associated with favorable clinical outcomes.
The features of the ReSCU include six private beds in a pulmonary inpatient ward staffed by nurses with special pulmonary expertise; 24-h respiratory therapy supervision; bedside and central noninvasive monitoring (i.e., continuous pulse oximetry, end tidal capnometry, and ventilator alarms); and a multidisciplinary approach involving dietitians, physical therapists, occupational therapists, social workers, and speech pathologists. All ReSCU patients were cared for primarily by a pulmonary/critical care attending physician and fellow, with consultative input solicited as deemed necessary. The criteria for admission to the ReSCU included hemodynamic stability; absence of an arrhythmia requiring telemetry; and in the attending physician's judgment, the ability to benefit from the ReSCU.
Between August 23, 1993, and August 31, 1997, 212 patients were admitted to the ReSCU. The median age was 68 years old; 55% were women; 86% were white; and 55% were transferred from the medical ICU. Underlying reasons for ventilator dependence were ARDS from a nonsurgical cause (33%), ARDS following surgery (18%), status post-cardiothoracic surgery (13%), status post-thoracic surgery (12%), and COPD (12%). The median length of ReSCU stay was 17 days (interquartile range, 10 to 29 days). Eighteen percent (n = 38) died during the hospitalization. Among the 174 survivors, complete ventilator independence was achieved in 127 patients (60% of the 212 patient cohort), 28 patients were ventilator dependent (13% of 212 patients), and the remaining 19 patients (9%) required partial ventilatory support. Univariate analysis regarding the association of baseline characteristics with death identified lower albumin and transferrin levels, increasing age, and the physician's estimate of lower weaning likelihood as significant correlates of death. In contrast, achieving complete ventilator independence was associated with a higher serum albumin level, a nonmedical ICU referral source, a cause of respiratory failure other than COPD, and a physician's estimate of higher weaning likelihood. To analyze the financial impact of the ReSCU, we assumed that ReSCU patients would have otherwise stayed in the medical ICU and compared the charges (ICU vs ReSCU) with, for a subset of patients, the true costs of ReSCU vs. ICU care. Analyses of both charges and cost differences showed similar savings associated with ReSCU care ($13,339 per patient [charges] and $10,694 per patient [costs]).
We conclude the following: (1) the rate of achieving complete ventilator independence in the ReSCU was high; and (2) based on our achieving clinical outcomes, which are comparable to the most favorable rates reported in other series from ventilator units, we conclude that the ReSCU can be an effective and cost-saving alternative to the ICU for carefully selected patients.
鉴于特殊撤机单元已被倡导作为重症监护病房(ICU)的有效替代方案,用于为特定患者撤机,我们于1993年8月在克利夫兰诊所医院设立了呼吸特殊护理单元(ReSCU)。ReSCU的目标如下:(1)尽可能为依赖呼吸机的患者撤机;(2)当无法撤机时,为带呼吸机回家的患者优化患者及家属指导。本研究展示了我们在ReSCU管理212例患者的4年经验,并分析了与良好临床结局相关的临床特征。
ReSCU的特点包括:在一个配备有具有特殊肺部专业知识护士的肺部住院病房中有6张私人病床;24小时呼吸治疗监督;床边和中心无创监测(即连续脉搏血氧饱和度监测、呼气末二氧化碳监测和呼吸机警报);以及多学科方法,涉及营养师、物理治疗师、职业治疗师、社会工作者和言语病理学家。所有ReSCU患者主要由一名肺部/重症监护主治医师和住院医师护理,必要时征求会诊意见。进入ReSCU的标准包括血流动力学稳定;不存在需要遥测的心律失常;且主治医师判断患者有能力从ReSCU中获益。
在1993年8月23日至1997年8月31日期间,212例患者被收治入ReSCU。中位年龄为68岁;55%为女性;86%为白人;55%从内科ICU转入。依赖呼吸机的潜在原因包括非手术原因导致的急性呼吸窘迫综合征(ARDS)(33%)、手术后ARDS(18%)、心胸外科手术后状态(13%)、胸外科手术后状态(12%)和慢性阻塞性肺疾病(COPD)(12%)。ReSCU住院时间的中位数为17天(四分位间距,10至29天)。18%(n = 38)的患者在住院期间死亡。在174名幸存者中,127例患者(占212例患者队列的60%)实现了完全脱机,28例患者仍依赖呼吸机(占212例患者的13%),其余19例患者(9%)需要部分通气支持。关于基线特征与死亡关联的单因素分析确定,较低的白蛋白和转铁蛋白水平、年龄增加以及医师估计的较低撤机可能性是死亡的显著相关因素。相比之下,实现完全脱机与较高的血清白蛋白水平、非内科ICU转诊来源、COPD以外的呼吸衰竭原因以及医师估计的较高撤机可能性相关。为分析ReSCU的财务影响,我们假设ReSCU患者否则将留在内科ICU,并比较了费用(ICU与ReSCU),对于一部分患者,还比较了ReSCU与ICU护理的实际成本。费用和成本差异分析均显示ReSCU护理有类似的节省(每位患者节省13,339美元[费用]和每位患者节省10,694美元[成本])。
我们得出以下结论:(1)ReSCU中实现完全脱机的比例很高;(2)基于我们取得的临床结局,与其他呼吸机单元系列报道的最有利比例相当,我们得出结论,对于精心挑选的患者,ReSCU可以是ICU的一种有效且节省成本的替代方案。