Robbins A H, Rosenfield A T, Pizzolato N F, Irwin G A, Putman C E, Gerzof S G, Ulreich S
AJR Am J Roentgenol. 1978 Dec;131(6):1043-6. doi: 10.2214/ajr.131.6.1043.
In a double-blind study of 283 patients (140 given iodamide and 143 diatrizoate), meglumine iodamide 24% produced a significantly greater degree of opacification than meglumine diatrizoate 30% (P less than 0.01 to P less than 0.001) in the renal calyces during the early phase of drip infusion pyelography. The agents were infused at a dose of 4.5 ml/kg, up to a maximum volume of 300 ml, over a period of about 10 min. The incidence and nature of laboratory abnormalities and clinical adverse reactions produced by the drugs were similar. No severe reactions occurred. The apparent superiority of the iodamide solution in the early stage of excretion, despite its lower iodine content, may be due to the partial secretion of iodamide by the renal tubules, as observed in other studies.
在一项针对283名患者的双盲研究中（140名给予碘酰胺，143名给予泛影葡胺），在静脉滴注肾盂造影的早期阶段，24%的碘酰胺葡甲胺在肾盏中产生的造影剂充盈程度明显高于30%的泛影葡胺（P小于0.01至P小于0.001）。这些药物以4.5毫升/千克的剂量进行输注，最大体积为300毫升，在约10分钟的时间内完成。药物产生的实验室异常和临床不良反应的发生率及性质相似。未发生严重反应。尽管碘酰胺溶液的碘含量较低，但其在排泄早期阶段的明显优势可能是由于肾小管对碘酰胺的部分分泌，正如其他研究所观察到的那样。
