Vergoni A V, Bertolini A, Wikberg J E, Schiöth H B
Department of Biomedical Sciences, University of Modena, Italy.
Peptides. 1999;20(4):509-13. doi: 10.1016/s0196-9781(99)00022-4.
CRF and melanocortin (MSH/ACTH) peptides share a number of central effects including anorexia and grooming. The effects of CRF may be secondary, due to CRF's effects on melanocortin peptide release. We investigated if the newly discovered selective melanocortin 4 receptor antagonist HS014 could influence CRF induced anorexia and grooming. The data show that ICV administration of CRF (3 mg/rat), significantly reduced food intake, feeding time and feeding episodes whereas it increased grooming time and grooming episodes. HS014 (5 mg/rat), that previously has been shown to antagonize the anorectic effect and the excessive grooming induced by alpha-MSH, did however not influence any of the behavioral effects induced by CRF when the peptides were administered together. The data indicate that the anorectic and grooming effects of CRF are independent of pathways involving the MC4 receptors. These data suggest that the anorectic and grooming effect of CRF are not due to a secondary effect caused by increase in release of melanocortins acting on the central MC receptors.
促肾上腺皮质激素释放因子（CRF）和促黑激素皮质素（MSH/ACTH）肽具有许多共同的中枢效应，包括厌食和梳理行为。CRF的效应可能是继发性的，因为CRF对促黑激素皮质素肽释放有影响。我们研究了新发现的选择性促黑激素皮质素4受体拮抗剂HS014是否会影响CRF诱导的厌食和梳理行为。数据显示，脑室内注射CRF（3毫克/大鼠）可显著减少食物摄入量、进食时间和进食次数，同时增加梳理时间和梳理次数。然而，先前已证明能拮抗α-MSH诱导的厌食效应和过度梳理行为的HS014（5毫克/大鼠），在与肽一起给药时，并未影响CRF诱导的任何行为效应。数据表明，CRF的厌食和梳理效应独立于涉及促黑激素皮质素4受体的途径。这些数据表明，CRF的厌食和梳理效应并非由作用于中枢促黑激素皮质素受体的促黑激素皮质素释放增加所引起的继发性效应所致。
