γ-微管蛋白复合体：大小至关重要。

Gamma-tubulin complexes: size does matter.

作者信息

Jeng R, Stearns T

机构信息

Dept of Biological Sciences, Stanford University, Stanford, CA 94305-5020, USA.

出版信息

Trends Cell Biol. 1999 Sep;9(9):339-42. doi: 10.1016/s0962-8924(99)01621-9.

DOI:10.1016/s0962-8924(99)01621-9

PMID:10461186

Abstract

gamma-Tubulin is a conserved component of all microtubule-organizing centres and is required for these organelles to nucleate microtubule polymerization. However, the mechanism of nucleation is not known. In addition to its localization to organizing centres, a large pool of gamma-tubulin exists in the cytoplasm in a complex with other proteins. The size of the gamma-tubulin complex and number of associated proteins vary among organisms, and the functional significance of these differences is unknown. Recently, the nature of these gamma-tubulin complexes has been explored in different organisms, and this has led us closer to a molecular understanding of microtubule nucleation.

摘要

γ-微管蛋白是所有微管组织中心的保守成分，是这些细胞器使微管聚合形成核所必需的。然而，成核机制尚不清楚。除了定位于组织中心外，大量的γ-微管蛋白以与其他蛋白质形成复合物的形式存在于细胞质中。γ-微管蛋白复合物的大小和相关蛋白质的数量在不同生物体中有所不同，这些差异的功能意义尚不清楚。最近，已在不同生物体中探索了这些γ-微管蛋白复合物的性质，这使我们更接近于从分子层面理解微管成核。