小鼠外侧背盖核中具有单胺氧化酶B（MAOB）活性的胆碱能神经元。

Cholinergic neurons with monoamine oxidase type B (MAOB)-activity in the laterodorsal tegmental nucleus of the mouse.

作者信息

Ikemoto K, Kitahama K, Maeda T, Jouvet M, Nagatsu I

机构信息

Department of Anatomy, Fujita Health University, School of Medicine, Aichi, Japan.

出版信息

Neurosci Lett. 1999 Aug 13;271(1):53-6. doi: 10.1016/s0304-3940(99)00512-1.

DOI:10.1016/s0304-3940(99)00512-1

PMID:10471212

Abstract

No neurons in the laterodorsal tegmental nucleus (LDTg) show monoamine oxidase (MAO) activity in the rat or monkey. However, in our recent study, many LDTg neurons with MAO type B (MAOB)-activity were found in MAOA-deficient mice that were derived from C3H mouse line. In the present study, LDTg neurons with MAOB-activity were found not only in normal C3H mouse but also in BALB/C and C57BL/6 mouse lines: MAO histochemistry revealed LDTg neurons with MAO-activity even after pharmacological suppression of MAOA-activity with clorgyline, a specific MAOA inhibitor, but not after pharmacological suppression of MAOB-activity with deprenyl, a specific MAOB inhibitor. LDTg neurons with MAOB-activity also showed NADPH-diaphorase-activity, a marker of cholinergic neurons.

摘要

在大鼠或猴子中，脑桥背外侧被盖核（LDTg）中没有神经元显示单胺氧化酶（MAO）活性。然而，在我们最近的研究中，在源自C3H小鼠品系的单胺氧化酶A（MAOA）缺陷小鼠中发现了许多具有B型单胺氧化酶（MAOB）活性的LDTg神经元。在本研究中，不仅在正常C3H小鼠中，而且在BALB/C和C57BL/6小鼠品系中都发现了具有MAOB活性的LDTg神经元：MAO组织化学显示，即使在用特异性MAOA抑制剂氯吉兰对MAOA活性进行药理学抑制后，LDTg神经元仍具有MAO活性，但在用特异性MAOB抑制剂司来吉兰对MAOB活性进行药理学抑制后则没有。具有MAOB活性的LDTg神经元也显示出NADPH-黄递酶活性，这是胆碱能神经元的一个标志物。