Martí-Climent J, Peñuelas I, Calvo R, Giménez M, Gámez C, Richter J
Servicio de Medicina Nuclear, Clínica Universitaria de Navarra, Pamplona, Navarra, 31008, España.
Rev Esp Med Nucl. 1999 Aug;18(4):261-7.
The experience acquired by our center during the first two years of using cyclotron 18/9 (IBA) dedicated to the production of clinical positron emission radionuclides is described. The cyclotron performance characteristics, production yields, quality control and synthesized radiotracers are analyzed. Cyclotron makes it possible to produce up to 3,300 mCi of 18F-, 270 mCi of 18F2, 3,100 mCi of 11C, 502 mCi of 13N (in 120, 60, 35 and 20 minutes respectively) and 540 mCi/min of 15O. In our center, about 85% of the PET studies are performed with 18F-FDG, whereas the remaining are done with 15O-water, 11C-bicarbonate, 11C-methionine, 13N-ammonia or 18F-. Cyclotron is included in the Radiopharmacy Unit of our PET facility and is subjected to a global quality control program. Follow-up of the bombardment parameters and periodic verifications of the cyclotron performance have made it possible to prevent equipment functioning problems, increase mean time between stoppage and decrease downtime. We conclude that cyclotron has high production capabilities and allows enough flexibility for a clinical and research positron emission tomography center; furthermore, it can also be used for regional distribution of 18F-FDG to satellite PET centers.
本文描述了我们中心在使用用于生产临床正电子发射放射性核素的回旋加速器18/9（IBA）的头两年中所获得的经验。分析了回旋加速器的性能特征、产量、质量控制以及合成的放射性示踪剂。该回旋加速器能够分别在120分钟、60分钟、35分钟和20分钟内生产高达3300毫居里的18F-、270毫居里的18F2、3100毫居里的11C、502毫居里的13N，以及每分钟540毫居里的15O。在我们中心，约85%的正电子发射断层显像（PET）研究使用18F-氟代脱氧葡萄糖（18F-FDG）进行，其余则使用15O-水、11C-碳酸氢盐、11C-蛋氨酸、13N-氨或18F-进行。回旋加速器隶属于我们PET设施的放射性药物部门，并接受全面的质量控制程序。对轰击参数的跟踪以及对回旋加速器性能的定期核查使得预防设备运行问题、增加两次停机之间的平均时间以及减少停机时间成为可能。我们得出结论，回旋加速器具有很高的生产能力，为临床和研究型正电子发射断层显像中心提供了足够的灵活性；此外，它还可用于向卫星PET中心进行18F-FDG的区域配送。
