系统性红斑狼疮患者抗Sm血清中针对核糖体蛋白S10的抗体活性频率较高。

High frequency of antibody activity against ribosomal protein S10 in anti-Sm sera from patients with systemic lupus erythematosus.

作者信息

Hasegawa H, Uchiumi T, Sato T, Ofuchi Y, Murakami S, Honda S, Hirose S, Ito S, Nakano M, Arakawa M, Gejyo F

机构信息

Department of Medicine (II), Niigata University School of Medicine, Asahimachi Dori 1-757, Niigata 951-8510, Japan.

出版信息

Lupus. 1999;8(6):439-43. doi: 10.1177/096120339900800605.

DOI:10.1177/096120339900800605

PMID:10483011

Abstract

This study was carried out to clarify the frequency of detection of antibody activity to ribosomal protein S10 (anti-S10) in patients with systemic lupus erythematosus (SLE) with anti-Sm antibodies (anti-Sm), and clinical differences between anti-Sm-positive SLE patients with and without anti-S10. Twenty-seven of 31 serum samples containing anti-Sm reacted with ribosomal protein S10 along with Sm core proteins B/B' and D (87.1%). Four serum samples containing anti-Sm against only B/B' but not D did not react with S10 (12.9%). Patients who had both anti-Sm and anti-S10 showed lower serum complements levels, high frequency of skin lesion and anti-double-stranded DNA antibody. Many anti-Sm antibodies may recognize B/B', D, and S10 simultaneously, and such antibodies may appear in active disease.

摘要

本研究旨在明确抗Sm抗体（anti-Sm）阳性的系统性红斑狼疮（SLE）患者中抗核糖体蛋白S10抗体活性（抗-S10）的检出频率，以及抗Sm阳性且抗-S10阳性和阴性的SLE患者之间的临床差异。31份含抗Sm的血清样本中有27份与核糖体蛋白S10以及Sm核心蛋白B/B'和D发生反应（87.1%）。4份仅含抗B/B'而不含抗D的抗Sm血清样本未与S10发生反应（12.9%）。同时具有抗Sm和抗-S10的患者血清补体水平较低，皮肤病变和抗双链DNA抗体的出现频率较高。许多抗Sm抗体可能同时识别B/B'、D和S10，且此类抗体可能出现在疾病活动期。