当突触失活时，成熟海马神经元上的树突棘更多。

Dendrites are more spiny on mature hippocampal neurons when synapses are inactivated.

作者信息

Kirov S A, Harris K M

机构信息

Division of Neuroscience in the Department of Neurology, Children's Hospital and Harvard Medical School, Enders 260, 300 Longwood Ave., Boston, Massachusetts 02115, USA.

出版信息

Nat Neurosci. 1999 Oct;2(10):878-83. doi: 10.1038/13178.

DOI:10.1038/13178

PMID:10491607

Abstract

Dendrites of CA1 pyramidal neurons in mature rat hippocampal slices were exposed to different levels of synaptic activation. In some slices, synaptic transmission was blocked with glutamate receptor antagonists, sodium and calcium channel blockers and/or a nominally calcium-free medium with high magnesium. In other slices, synapses were activated with low-frequency control stimulation or repeated tetanic stimulation. In slices with blocked synaptic transmission, dendrites were spinier than in either of the activated states. Thus, mature neurons can increase their numbers of spines, possibly compensating for lost synaptic activity.

摘要

在成熟大鼠海马切片中，CA1锥体神经元的树突暴露于不同水平的突触激活状态。在一些切片中，用谷氨酸受体拮抗剂、钠和钙通道阻滞剂和/或含有高镁的无钙培养基阻断突触传递。在其他切片中，用低频对照刺激或重复强直刺激激活突触。在突触传递被阻断的切片中，树突比在任何一种激活状态下都有更多的棘。因此，成熟神经元可以增加其棘的数量，可能是为了补偿失去的突触活动。