糖重折叠在溶液中DNA的A和B形式转变中的作用。一项分子动力学研究。
Role of sugar re-puckering in the transition of A and B forms of DNA in solution. A molecular dynamics study.
作者信息
Soliva R, Luque F J, Alhambra C, Orozco M
机构信息
Departament de Bioquímica i Biologia Molecular, Facultat de Química, Universitat de Barcelona, Spain.
出版信息
J Biomol Struct Dyn. 1999 Aug;17(1):89-99. doi: 10.1080/07391102.1999.10508343.
Abstract
State of the art molecular dynamic simulations show that simple modification of the sugar puckering of 2'deoxyriboses leads to a reversible change between two stable forms of DNA which resemble very closely the canonical A and B duplex forms. Analysis of the A-type and B-type structures reveals interesting, and previously unknown features of these two families of conformations of the DNA.
摘要
最新的分子动力学模拟表明，对2'-脱氧核糖的糖环构象进行简单修饰会导致DNA的两种稳定形式之间发生可逆变化，这两种形式与典型的A和B双链体形式非常相似。对A型和B型结构的分析揭示了这两类DNA构象中有趣的、此前未知的特征。
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