异种移植的最新进展。

Recent advances in xenotransplantation.

作者信息

Sandrin M S, McKenzie I F

机构信息

Molecular Immunogenetics Laboratory, Austin Research Institute, Austin and Repatriation Medical Centre, Studley Road, Heidelberg, Victoria, 3084, Australia.

出版信息

Curr Opin Immunol. 1999 Oct;11(5):527-31. doi: 10.1016/s0952-7915(99)00011-4.

DOI:10.1016/s0952-7915(99)00011-4

PMID:10508710

Abstract

The major barrier to clinically successful pig-to-human xenotransplantation is antibody- and complement-dependent hyperacute rejection, known to be due to host anti-Galalpha(1,3)Gal antibodies. Strategies aimed at eliminating hyperacute rejection involve transgenic approaches to eliminate or reduce expression of Galalpha(1,3)Gal or to reduce complement activation; some of these are now in clinical trials in primates. Another important role of Galalpha(1,3)Gal that is becoming more evident is in antibody-dependent and -independent xenograft rejection that is mediated by natural killer cells and monocytes.

摘要

猪到人的临床成功异种移植的主要障碍是抗体和补体依赖性超急性排斥反应，已知这是由于宿主抗Galα(1,3)Gal抗体所致。旨在消除超急性排斥反应的策略包括通过转基因方法消除或减少Galα(1,3)Gal的表达或减少补体激活；其中一些目前正在灵长类动物中进行临床试验。Galα(1,3)Gal的另一个越来越明显的重要作用是在由自然杀伤细胞和单核细胞介导的抗体依赖性和非依赖性异种移植排斥反应中。